Join the Slack for updates on presentations and post-talk questions and discussion with the presenter!

Link to Google Calendar of talks

Symposium Talks are typically Wednesdays at 9am PT, 11 CT, 12pm ET Meeting Link
Webinar ID: 833-8631-0168 // Password: 778156

Aging Science Talks FAQ.

Presenters: Please join 15 minutes in advance of your talk time. Please also sign up for the slack in advance - questions will post in a dedicated thread.

Dec 1, 2021 12-2pm ET/11am-1pm CT/9-11am PT

Aging and Urology, Chair: Teresa Liu, PhD

Scott Bauer, MD, MS, Using Phenotypic and Functional Aging Relationships to Guide Mechanistic Investigations of Age-related Lower Urinary Tract Symptoms
Laura Pascal, PhD: Aging and E-cadherin deficiency contribute to prostate inflammation and bladder overactivity
Alexis Adrian: The Aging Powerhouse: Mitochondrial Dysfunction in Benign Prostatic Hyperplasia (BPH)

Previous weeks talks

Week 1

March 18: Dr. Dudley Lamming, The regulation of health and longevity by dietary macronutrients
March 19: Dr. Marianna Sadagurski, Glia in aging brain and anti-aging interventions under stress
March 20: Dr. Javier Apfeld, C. elegans processes sensory information to choose between freeloading and self-defense strategies

Week 2

March 23: Double Feature: 1st: Dr. Danielle Mor, The discovery of new candidate disease genes, mechanisms, and therapies for Parkinson's, 2nd: Dr. Garik Mkrtchyan, Deep learned drugs for DNA repair
March 24: AFAR Webinar: "AFAR Webinar: COVID-19: Can the Science of Aging move us Forward" Zoom link: https://t.e2ma.net/click/6hk5pb/uwnk7m/ynv3ph
March 25: Dr. Daniel Promislow, The Dog Aging Project: How Genes and Environment Shape Healthy Aging
March 26: Dr. Emily Goldberg, Defects in adipose-resident immune cells underlie age-related metabolic defects
March 27: Dr. Connie Cortes, Enhanced Skeletal Muscle Proteostasis as a Novel Determinant of CNS Aging and Disease

Week 3

March 30: Mike MacArthur, A multi-omics assessment of dietary protein titration
March 31: Dr. Cara Green, Sex and genetic background define the metabolic, physiological and molecular response to protein restriction
April 1: Nalle Pentinmikko, Aging intestine and misbehaving stem cell niche
April 2: Dr. Roberto Zoncu, Molecular mechanisms of lysosomal mTORC1 signaling
April 3: Dr. Helen Goodridge, Role of hematopoietic aging in cognitive decline

Week 4

April 6: Dr. Jenny Regan, Sex dimorphisms in innate immunity and ageing
April 7: Dr. Dorota Skowronska-Krawczyk, Aging membranes - lesson from the retina
April 8: Dr. Samir Morsli, Zebrafish as a model of ageing and senescence
April 9: Dr. Christian Sell, Metabolic influence on senescence as a cell fate decision
April 10: Dr. Kasia Golajnek-Whysall, microRNA-mediated regulation of skeletal msucle ageing

Week 5

April 13: Dr. Karthikeyani Chellappa, Bidirectional interaction between host and microbes to maintain organismal NAD homeostasis
April 14: Dr. Payel Sen, High-throughput chromatin screens to identify targets of senescence and aging
April 15: Dr. Matt Yousefzadeh, An aged immune system drives senescence and dysfunction in solid organs
April 16: Dr. Yuancheng Lu, Reversal of injury- or aging-induced vision loss by Tet-dependent in vivo epigenetic reprogramming
April 17: Dr. Daniel Trott, Role of the immune system in cardiovascular aging

Week 6

April 20: Dr. Nikki Noren Hooten, Extracellular vesicles in aging and age-related disease
April 21: Dr. Duygu Ucar, Sexual dimorphism in human immune system aging
April 22: Dr. Berenice Benayoun, Emerging regulatory mechanisms in vertebrate aging
April 23: Dr. Dan Tyrrell, Role of mitochondria in vascular (and cerebrovascular) aging and disease
April 24: Miriam Alberni, The impact of Drp1 phosphorylation sites on mitochondrial dynamics and metabolic adaptation

Week 7

April 27: Dr. Martin Denzel, eIF2B extends lifespan through inhibition of the integrated stress response
April 28: Dr. Meng Wang, Signaling Role of Metabolites in Longevity Regulation
April 29: Dr. Sean Curran, Transcriptional redirection as a strategy to improve healthspan
April 30: Dr. Alessandro Ori, Proteomics of Stem Cell Aging
May 1: Dr. Weiwei Dang, Lifespan extension by novel chromatin-regulated stress response pathways

Week 8

May 4: Dr. Darcie Moore, Proteostatic control of quiescence exit in mammalian neural stem cells

Aging Science Talks Global Event! May 4 and 5th

Event Schedule with multiple time zones listed

Dr. Matthew Piper, Dietary Restriction in Drosophila: long lived or less sick?

Dr. Brian Kennedy, TBD

Dr. Lena Pernas, Mitochondrial metabolism in defense against microbes

Dr. William Mair, RNA Splicing and Longevity Interventions

Dr. Dena Dubal, Role of the X Chromosome in Aging and Neurodegenerative Disease

May 6: Sun Maybury-Lewis, Decoding age-associated dynamics of chromatin accessibility in neural stem cell activation
May 7: Dr. Marcelo A. Mori, Changes in miRNA biogenesis and their role in metabolism and aging
May 8: Dr. Adam Salmon, Rapamycin intervention to promote non-human primate lifespan

Week 9

May 11 UK Talk: Dr. Jenny Tullet, Neuronal SKN-1B Modulates TGF-beta and Insulin/IGF-1-like Signalling to Control Satiety
May 11: Dr. Amy Walker, Differential roles of SAM synthases in aging and stress responses in C.elegans
May 11/12: Asia/Pacific Talk: Dr. Lindsay Wu, Metabolic changes as a cause of reproductive ageing: NAD+ and the PPP
May 12: Dr. Alice Kane, Age and life expectancy clocks based on machine learning analysis of mouse frailty
May 13: Dr. Hua Bai, Peroxisome aging and inter-organ communication
May 14 UK Talk: Dr. Joris Deelen, The genetics of human longevity
May 14: Dr. Farners Amargant i Riera, The aging ovarian microenvironment: linking stromal fibrosis and the hyaluronan matrix
May 15: Dr. Christy Carter, The aging gut microbiome and disease

Week 10

May 18 UK Talk: Dr. Nazif Alic, Odd Pols in ageing
May 18: Dr. Sarah Mitchell, Late life interventions to improve health in mice
May 18/19: Asia/Pacific Talk: Dr. Oliver Dreesen, The role of heterochromatin in the accelerated aging syndrome Hutchinson-Gilford progeria
May 19: Dr. Juan Manuel Vazquez, Gene Duplication and Peto's Paradox in Afrotheria
May 20: Dr. Jessica Hoffman, Gene and metabolic regulation of temperature dependent longevity in D. melanogaster: A pilot study
May 21 UK Talk: Dr. Mireya Vazquez-Prada, Do host-microbe interactions affect ageing? Establishing causation in the model organism C.elegans
May 21: Dr. Dario Riccardo Valenzano, African killifishes shed light on evolution and modulation of vertebrate lifespan
May 22: Dr. Magdalena Misiak-Christian, TBD

Week 11

May 25: UK Talk: Dr. Eugenia Goya, Probiotic Bacillus Subtilis protects from PD-associated alpha-synuclein aggregation in C. elegans
May 25: US Holiday - Memorial Day - No Talks
May 25/26: Asia/Pacific Talk: Alistair Senior, Macronutrients, Age-Specific Mortality and Lifespan
May 26: Spencer Haws, Protective roles for epigenetic adaptation to metabolic stress
May 27: Yasmine Liu, Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30
May 28 UK Talk: Dr. Stephen Wilkie, TBD
May 28: Robert Signer, Hematopoietic Stem Cell Regulation by the Proteostasis Network
May 29: Helena Cocheme, TBD

Week 12

June 1: UK/EU Talk: Dr. Maria Mittelbrunn, Immunometabolism in age-related diseases
June 1/2: Asia/Pacific Talk: Amelia Fotheringham, Can diet damage the kidney? Using the geometric framework for nutrition to explore the role of macronutrient consumption on kidney structural and functional outcomes with aging.
June 2: Cancelled
June 4: UK/EU Talk: Dr. Della David, Age-dependent protein aggregation and its regulation
June 4: Dr. Michael Lustgarten, The Gut-Muscle Axis in Older Adults

Week 13

June 8/9: Asia-Pacific Talk: Dr. Tara-Lyn Camilleri-Carter, Transgenerational effects of diet on offspring lifespan
June 9: Dr. Dhaval Patel, Modulation of Lifespan by Food and Temperature in C. elegans
June 11: Dr. Ambre Sala, Embryo Integrity Regulates Proteostasis and Stress Resilience

Week 14

June 15/16: Asia-Pacific Talk: Dr. Julio Aguado, TBD
June 16: Dr. Savraj Grewal, Adipose TOR kinase signaling and the control of growth and stress responses in Drosophila
June 17: AGE Virtual Meeting - No @AgeSciTalks. Register at https://www.americanagingassociation.org/virtual-meeting
June 18: AGE Virtual Meeting - No @AgeSciTalks. Register at https://www.americanagingassociation.org/virtual-meeting
June 19: AGE Virtual Meeting - No @AgeSciTalks. Register at https://www.americanagingassociation.org/virtual-meeting

Week 15

June 23/23: Asia-Pacific Talk: Dr. Javier Gomez Ortega, TBD
June 23: Dr. Myriam Chimen, A novel pathway controlling T-cell trafficking during inflammation is dysregulated in chronic inflammatory diseases and ageing.
June 24: UK/EU Talk: Shahaf Peleg, Metabolism and epigenetics in early aging in Titan/Rock mice and flies
June 25: Alessandro Bitto, Geroscience approaches to mitochondrial disease and diet-induced obesity.

Week 16

June 29/30: Asia-Pacific Talk: Dr. Damian Dowling, TBD
June 30: Dr. Mirre Simons, Understanding the biology of ageing through the demography of death
July 2: Dr. Suzanne Angeli, The Mitochondrial Permeability Transition Pore Activates a Maladaptive Mitochondrial UPR

Week 17

July 6/7: Asia-Pacific Talk: Dr. Chris Proud, TBD
July 7: Dr. Anthony Covarrubias, Mechanistic insight how aging-related inflammation impacts tissue NAD levels
July 9: Special Event: Aging Muscle - Dr. Irina Conboy, Dr. David Glass, Dr. Holly Van Remmen, Dr. Susan Howlett

Week 18

July 13/14: Asia-Pacific Talk: Dr. Philip Sheard, Investigating cellular processes involved in age-related loss of skeletal muscle in mice.
July 14: Double Feature: 1st, Dr. Jorge Castillo-Quan, TBD; 2nd, Dr. Jonathan An, TBD
July 16: Dr. Ryo Higuchi-Sanabria, More than just a load control: Form and function of actin during aging

Week 19

July 20/21: Asia-Pacific Talk: Dr. Volker Patzel, Exploring RNA technologies for healthy longevity
July 21: Dr. Tim Rhoads, Monkeying around with molecular profiling
July 23: Dr. Chenglong Xie, Deep learning to screen mitophagy inducers

Week 20

July 27/28: Asia-Pacific Talk: Dr. John Chua, Exploring RNA technologies for healthy longevity
July 28: Dr. Inca Dieterich, TBD
July 30: Dr. Guofeng Lou, APOE4 and Mitophagy Project

Week 21

August 2/3: Asia-Pacific Talk: Dr. Mark Tomas Mc Auley, How Aging Impacts Folate & Cholesterol Metabolism- Computational & Electrochemical Approaches.
August 4: Dr. Anne Brunet, TBD
August 6: Dr. Eric Greer, Ribosomal RNA Methylation Regulates the Stress Response

Week 22

August 10/11: Asia-Pacific Talk: Nicholas Hunt, Nanomedicine in ageing
August 13: Dr. Stanislava Chtarbanova, Investigating host-virus interactions in aged Drosophila

Week 23

August 18: Dr. Joao Pedro Magalhaes, Solving ageing from home with computational approaches
August 20: Dr. Nan Hao, Divergent trajectories of single-cell aging

Week 24

August 25: Dr. Susanna Rosi, Small molecule cognitive enhancer reverses age-related memory decline in mice

September 9, 2020 12-2pm ET/11am-1pm CT/9am-11am PT

Protein quality control - Basic mechanisms and new perspectives in the biology of aging, Chair: Martin Denzel

David Ron, University of Cambridge, Targeting the Integrated Stress Response
Bernd Bukau, Heidelberg University and DKFZ, Molecular dissection of amyloid disaggregation by the human Hsp70 chaperone machinery
Ashley Frakes, UC Berkeley, Glia regulate ER stress resistance and longevity
Della David, University of Tubingen, Deciphering extracellular protein quality control in C. elegans

September 16, 2020 12-2pm ET/11am-1pm CT/9am-11am PT

Unraveling the Mysteries of the Aging Brain in Health and Disease Part 1, Chair: Marianna Sadagurski

Shane Liddelow, New York University, What do reactive astrocytes do?
Shannon Moore, University of Michigan, TBA

September 23, 2020 12-2pm ET/11am-1pm CT/9am-11am PT

Unraveling the Mysteries of the Aging Brain in Health and Disease Part 2, Chair: Marianna Sadagurski

Jonathan Kipnis, Washington University, Meningeal lymphatics In Aging And Alzheimer�s Disease
Tony Wyss-Coray, Stanford University, Young blood for old brains

October 6,2020 12-2pm ET/11am-1pm CT/9am-11am PT

Senescence and aging: chromatin gone awry, Chair: Payel Sen

Shelley Berger, University of Pennsylvania, Profound nuclear and chromatin alterations in senescence and aging
Isabel Beerman, Effects of caloric restriction on the epigenetic profiles of aged hematopoietic stem cells
John Sedivy, TBD
Alejandro Ocampo, TBD

October 21, 2020 12-2pm ET/11am-1pm CT/9am-11am PT

Mechanisms of declining protective immunity despite heightened chronic inflammation during aging, Chair: Emily Goldberg

Dawn Bowdish, Secrets of the super-centenarians: The immunology of aging well
Mladen Jergovic, IL-6 can singlehandedly drive many features of frailty in mice
Elsa Bou Ghanem, Neutrophil responses against S. pneumoniae in aged hosts
Dan Winer, Mechanical Stiffness Controls Immune cell Metabolism and Function

November 4, 2020 12-2pm ET/11am-1pm CT/9am-11am PT

Immunosenescence: Basic mechanisms and clinical perspectives of immune aging, Chair: Matt Yousefzadeh

Antoneta Granic, Immunosenescence profiles and muscle health in the very old: The Newcastle 85+ Study
Sian Henson, GATA3 controls mitochondrial biogenesis in T cells during DNA damage
Christina Camell, Senolytics reduce coronavirus-related mortality in aged mice
Joan Mannick, Targeting mTOR to Improve the Function of the Aging Immune System

November 18, 2020 (5-7pm ET/11pm-1am EU), November 19 (9-11am East Australia) 12-2pm ET/11am-1pm CT/9am-11am PT

Sex, Stress, Diet and Death, Chair: Matt Piper

Yang Lyu, Serotonin 2A receptor coordinates central metabolic processes to modulate aging and physiology in response to nutrient choice
Cara Green, Sex and Strain Determine the Metabolic Response to Dietary Protein Level
Kenneth Wilson, The role of genetic variation in lifespan and healthspan response to dietary restriction
Samantha Solon-Biet, Nutrition, reproduction and ageing: a life course approach

December 2, 2020 12-2pm ET/11am-1pm CT/9am-11am PT

Aging and metabolic disease, Chair: Cara Green

Mirela Delibegovic, Methionine restriction and metabolism during ageing in mice
Cristal Hill, Effects of dietary protein restriction on metabolism: A case for FGF21 signaling
Gemma Casadesus, Deciphering the role of the metabolic hormone Amylin in AD development and prevention
Nicole Richardson, The Regulation of Metabolic Health and Longevity by Dietary Branched-Chain Amino Acids

December 21, 2020 12-2pm ET/11am-1pm CT/9am-11am PT

Omics of healthy aging - When big data provides a new window into healthy aging, Chair: Berenice Benayoun

Bryan Teefy, PIWI-piRNA Pathway-Mediated Transposable Element Repression in Hydra Somatic Stem Cells
Marc Vermulst, TBD
Serban Ciotlos, Multi-omic analysis of deep cell senescence
Kevin Contrepois, Molecular Choreography of Acute Exercise

January 20, 2021 12-2pm ET/11am-1pm CT/9am-11am PT

How aging and disease drive stem cell dysfunction, Chair: Darcie Moore

Yukiko Yamashita, Non-random sister chromatid segregation and ribosomal DNA maintenance
Maria Llorens-Martin, Human adult hippocampal neurogenesis during physiological and pathological aging
Saul Villeda, Bloodborne factors driving brain aging
Marlen Knobloch, Modulating lipid metabolism to alter stem cell behavior

February 3, 2021 12-2:30pm ET/11am-1pm CT/9am-11am PT

Exercise and Aging: Geroprotection on the Treadmill, Chair: Constanza Cortes

Sue Bodine, Adaptive response of F344 rats to 8 weeks of treadmill training: age and gender comparisons
Jessica Scott, Exercise Across the Cancer Continuum to Modulate Therapy-Related Accelerated Aging
Nathan LeBrasseur, TBD
Christiane Wrann, TBD
Kaleen Lavin, Muscle Transcriptional Networks Linked to Resistance Exercise Training Hypertrophic Response Heterogeneity

Thursday: February 18, 2021 12-4:20pm ET/11am-3:20pm CT/9am-1:20pm PT

2nd Annual Symposium of the Midwest Aging Consortium, Chair: Daniella Elyse Chusyd

Welcome Address, Roz Anderson, PhD, University of Wisconsin-Madison
Keynote: Beyond the Calorie: Restricting specific dietary macronutrients to promote health and longevity, Dudley Lamming, PhD, University of Wisconsin-Madison
Senescence Biomarkers as Determinants of Late-life Health and Function, Davis Englund, PhD, Mayo Clinic
Maternal Serotonin Protects Future Progeny from Thermal Stress by Modulating Histone Occupancy in Germ Cells, Srijit Das, PhD University of Iowa
Mitochondrial Transcription Factor A is Required for Alveolar Macrophage Development, Mariana Herrerias, PhD, Northwestern University
An Aged Immune System Drives Senescence and Aging of Solid Organs, Matt Yousefzadeh, PhD, University of Minnesota
Dysfunction of Microglial Proteostasis Drive Neuroinflammation and Cognitive Decline Following Pneumonia, Rogan Grant, Northwestern University
Caloric Restriction Induces Unique Transcriptional Responses Between Adipose Depots in Rhesus Monkeys, Josef Clark, PhD, University of Wisconsin-Madison
Fasting Drives the Metabolic, Molecular, and Geroprotective Effects of a Calorie Restricted Diet, Heidi Pak, University of Wisconsin-Madison
Human Aging: What We Can Learn from the Elephant, Daniella Chusyd, PhD, Indiana University
Peroxisomal Dysfunction Disrupt Mitochondrial Dynamics Through mTORC2, Peiduo Liu, Iowa State University
Concluding Remarks, Paul Robbins, PhD, University of Minnesota

March 10, 2021 1-3pm ET/12pm-2pm CT/10am-12pm PT

Not An Aging Science Talks Event: UAB Nathan Shock Center Pilot Awardees Symposium (registration required: https://www.uab.edu/shockcenter/news-events/symposium/symposium-2021).

Welcome and Introduction, Steven Austad and Thomas Buford
Dao-Fu Dai, MD, PhD, TBD
Merry-Lynn McDonald, PhD, Plasma Vitamin E levels are significantly associated with skeletal muscle citrate synthase activity in COPD
Dudley Lamming, PhD, Fasting Drives the Metabolic, Molecular and Geroprotective Effects of a Calorie Restricted Diet
Scott Phillips, PhD, A Novel Ferret Model of Idiopathic Pulmonary Fibrosis
Josh Stern, PhD, TBD
Michael Stout, PhD, Potential mechanisms by which 17a-E2 alters aging in a sexually-divergent manner
Round Table Discussion

March 23, 2021 12-2pm ET/11am-1pm CT/9am-11am PT

Frailty: Quantifying Heterogeneity in Aging, Chair: Alice Kane

Gordan Lithgow, Compressing morbidity by an aging intervention
Danielle Bruns, Rapamycin, metformin, and the aging right heart
Melissa Emery Thompson, Musculoskeletal aging in wild chimpanzees: successful aging in a physically demanding environment
Andrew Rutenberg, Embracing the complexity of aging with the help of computational models

April 13, 2021 12-2pm ET/11am-1pm CT/9am-11am PT

Lipid metabolism and aging, Chair: Dorota Skowronska-Krawczyk

Itay Budin, Lipid membranes in aging
Priyanka Narayan, A metabolic basis for Alzheimer�s disease risk
Peter Tessarz, Single cell epigenomic analysis reveals zonation-specific differences in the ageing of liver and establishes organoids as an ex vivo model system for ageing research.
Judith Campisi, Bioactive lipids comprise the senescence-associated secretory phenotype (SASP)

April 21, 2021 12-2pm ET/11am-1pm CT/9am-11am PT

Peroxisome, Metabolism, and Homeostasis, Chair: Hua Bai

Irfan Lodhi, Peroxisomal control of energy metabolism
Andrew Simmonds, Shared Pex proteins coordinate lipid droplet and peroxisome activities in Drosophila
Margret Bulow, Peroxisome - mitochondria communication influences sphingolipid homeostasis
Francesca Di Cara, Peroxisomes in immunity and inflammation

May 5, 2021 12-2pm ET/11am-1pm CT/9am-11am PT

Linking cellular senescence to aging, Chair: Ana O'Loghlen

Raffaella di Micco, Dissecting the role of senescence-related programs during Hematopoietic Stem Cell aging
Darren J. Baker, Degeneration mediated by cellular senescence
Birgit Schilling, TBD
Jennifer Elisseeff, Aging and tissue repair � do we have a chance?

May 19, 2021 12-2pm ET/11am-1pm CT/9am-11am PT

Nutrient signaling and aging, Chair: Cristal Hill

Jessica Hoffman, The role of tryptophan metabolism on aging across species
Hannah Fang, FGF21 prevents low protein diet-induced renal inflammation in aged mice
Reyhan Westbrook, Kynurenines link chronic inflammation to functional decline, physical frailty and aging

June 2, 2021 12-2pm ET/11am-1pm CT/9am-11am PT

Machine Learning for Aging - Deep Phenotyping for Aging, Chair: Nicolette Laird

Morten Scheibye-Knudsen, Interventions in Aging
Jude Phillip, Ageing at cell resolution
Christopher Fang-Yen, Tools for automating genetics and aging in C. elegans
Rex Kerr, Phenotyping Aging with the C. elegans Observatory

June 23, 2021 12-2pm ET/11am-1pm CT/9am-11am PT

Applied AI in Aging Research, Chair: Nicolette Laird

Adriana San-Miguel, Deep-learning identifies distinct neurodegenerative phenotypes in C. elegans
Indra Heckenbach, Deep Learning can predict senescence from nuclear morphology across tissues and species
Morgan Levine, TBD
Panel Q&A

October 20-21, 2021 9-11am ET/8-10am CT/6-8am PT

Sulfur Amino Acid Restriction (SAAR) - Moving from Animal Models to Humans, Chair: Sailendra N Nichenametla

October 20, 2021

Sailendra N Nichenametla, SAAR: A brief introduction
John P Richie Jr., SAAR: Translational Implications
Amany Elshorbagy, Circulating SAA, Adipogenesis, and Diabetes Risk
Thomas Olsen, Dietary SAAR with (mostly) Whole Foods in Normal-weight, Overweight and Obese Individuals
Q&A

October 21, 2021

Zhen Dong, Long-term Intake of SAA and Diabetes Risk
Kumar Sambamurti, Can SAAR Prevent Neurodegeneration?
Jay Johnson, Do Healthspan-extending Interventions (Including SAAR) Merely Counteract the Deleterious Effects of Overnutrition?
Q&A
Panel Discussion